Disseminated intravascular coagulation (DIC) has a common pathogenesis in terms of persistent widespread\nactivation of coagulation in the presence of underlying disease, but the degree of fibrinolytic activation often differs\nby DIC type. DIC with suppressed fibrinolysis is a DIC type usually seen in sepsis. Coagulation activation is severe,\nbut fibrinolytic activation is mild. DIC with enhanced fibrinolysis is a DIC type usually seen in acute promyelocytic\nleukemia (APL). Both coagulation activation and fibrinolytic activation are severe. DIC with balanced fibrinolysis is a\nDIC type usually seen in solid tumors, with an intermediate pathogenesis between the above two types. In animal\nDIC models, lipopolysaccharide (LPS)-induced models are similar to suppressed-fibrinolytic-type DIC, whereas tissue\nfactor (TF)-induced models are similar to enhanced fibrinolytic/balanced fibrinolytic DIC. Appropriate diagnosis and\ntreatment may also differ depending on the DIC type.
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